You come up with a neat idea. You're very creative, and your first 20 performances (that's what they are) are HILARIOUS! You find yourself with several hundred thousand followers on YouTube in a month.
As the counter approaches a million, the paychecks start to arrive. Your name spreads. The counter starts towards your second million (and more). You have more material, Recording is so fun, and the numbers climb every time you release something new. There's such a huge connection between you and your fans!
About 6 months in, there's a week when you don't feel creative. You don't release anything that week - just as a break. Even working schlubs get 2 weeks a year off, right? When nothing new shows up, the subscribers start falling. You were never really in it for the money, but that falls, too. It's so easy for fans to just move on to the "next big thing".
After a year, it isn't fun any more. If you're not funny and engaging every week, you're finished. Even though no one asked you to, you feel an obligation to your audience to keep it going. What started out as a lark and creative outlet is now just one big rocky burden. It won't ever end, and quitting is unthinkable.
I can easily see where depression and hopelessness would be a thing. Add to that the fact that the computer screen seems to make us all completely sociopathic towards whomever is on the other end, treating them as cardboard cutout targets for our own (not so) witty abuse, and we've built a very dangerous playground for humans.