https://www.newscientist.com/article/2492205-mrna-drugs-could-protect-against-almost-any-kind-of-viral-infection/

https://www.nature.com/articles/s41541-025-01251-5

LIB,MR BEARS said:

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KaiBear said:

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Just concluded dinner with a retired immunologist.

She said this RNA research has been ongoing for many years with few tangible results.

At least so far.

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That$ a $tupid comment. The result$ have been $ignificant

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You are right

Key Breakthroughs in mRNA Research

1. Quantum Computing Meets mRNA Design
A collaboration between IBM and Moderna achieved the first-ever quantum simulation of a 60-nucleotide mRNA structure, surpassing prior records and suggesting a future where quantum methods can more precisely model mRNA folding and design for improved vaccine and therapeutic performance.Live Science

2. mRNA-Based Cancer Therapy Progress
Researchers at the Children's Hospital of Philadelphia (CHOP) uncovered that specific mRNA fragmentsabsent in pediatric high-grade gliomascan sensitize these tumors to immunotherapy, offering hope for advancements in pediatric cancer treatment.Mirage News

3. mRNA COVID-19 VaccinemNEXSPIKE (mRNA-1283)
Moderna's next-generation COVID-19 vaccine candidate, mRNA-1283 (mNEXSPIKE), has been FDA-approved (May 30, 2025) for adults 65+ and individuals 1264 with comorbidities. It features improved logistics, including standard refrigeration storage and prefilled syringes.Wikipedia

4. Expanding Cancer Vaccine Innovations

• mRNA-4157/V940, a personalized mRNA cancer vaccine developed by Moderna and Merck, reduced the risk of recurrence by 44% in stage III/IV melanoma patients when paired with pembrolizumab (KEYNOTE-942 Phase IIb trial)GENWikipedia.
• Autogene cevumeran, a BioNTechGenentech individualized vaccine for pancreatic cancer, showed preliminary efficacy and safety with responders demonstrating no recurrence at 18 months vs. a 13.4-month median in non-respondersWikipedia.

5. Innovative Delivery Methods

• Moderna has developed a lung-targeted lipid nanoparticle (LNP) formulation for inhalable mRNA deliverypotentially enabling treatments for pulmonary diseases like cystic fibrosis.BioSpace
• Self-amplifying RNA (saRNA) platforms are gaining traction, offering enhanced protein expression at lower doses and prolonged activitymarking a next-gen leap in mRNA technology.Wikipedia

6. AI-Driven mRNA Optimization

• RNop, a new deep learning model, can design mRNA sequences with high fidelity, species-specific codon use, efficient translation, and desired structureboosting both computational speed and expression effectiveness.arXiv
• Helix-mRNA, a hybrid foundation model, enhances design across coding and untranslated regions (UTRs) of mRNA sequences with high efficiencyprocessing longer sequences with fewer parameters.arXiv
• mRNA folding algorithms are being developed to co-optimize structure and codon choice, tackling mRNA instability challenges for better storage, distribution, and efficacy.arXiv

7. Growth in Therapeutic Development

• Moderna is progressing mRNA treatments for rare metabolic diseases:
  
  • mRNA-3927 (propionic acidemia) showed a 72% drop in metabolic crises.
  • mRNA-3705 (methylmalonic acidemia) is set for pivotal trials after FDA's START program selection.AInvest
• A recent market report highlights over 235 mRNA drug candidates, 170+ trials, and robust investment across disease targetsindicating mRNA's broad and expanding potential.GlobeNewswire

8. Widening Therapeutic Horizons

• Autoimmune disease therapies: mRNA approaches are in preclinical stages to reset immune tolerancepotentially transforming treatment for conditions like multiple sclerosis, rheumatoid arthritis, and type 1 diabetes.Healthcare Insightsmalik ventures
• Infectious diseases beyond COVID-19: mRNA vaccines are being designed for intracellular pathogens (e.g., Brucella), potentially unlocking responses that traditional vaccines can't.Frontiers
• mRNA RSV vaccines (e.g., mRESVIA) received FDA approval in 2024 for adults 60+, showcasing storage and stability improvements.

https://time.com/7309755/cutting-mrna-research-deadly-mistake/

https://www.cidrap.umn.edu/covid-19/virologist-network-reaffirms-support-mrna-vaccine-platform

Nicole Shanahan just hosted the most censored woman in America.

This Wall Street executive abandoned her career after a Pharma CEO told her that he knew their new drug would kill people—but “we can still make $7 billion” from it.

Now, she is Pharma’s worst nightmare.

🧵THREAD pic.twitter.com/WAtiArUnyQ

— Holden Culotta (@Holden_Culotta) August 14, 2025

Prof. Brett Weinstein who once hailed vaccines as a modern day triumph is now determined to explain why he was wrong.

In a candid discussion with Piers Morgan he
described how the mRNA platform is fatally flawed, dangerous and inferior to naturally immunity.

But he wasn’t done… pic.twitter.com/2W7zDsupPs

— Kat A 🌸 (@SaiKate108) August 15, 2025

Another article on the problems with experimental vaccines:

https://pjmedia.com/matt-margolis/2025/08/16/the-legacy-media-wont-touch-these-explosive-mrna-vaccine-study-findings-n4942757

historian said:

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Another article on the problems with experimental vaccines:

https://pjmedia.com/matt-margolis/2025/08/16/the-legacy-media-wont-touch-these-explosive-mrna-vaccine-study-findings-n4942757

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You really should check your sources before you post such bogus garbage. PJ media is a known nut job conspiracy site.

• A Swiss team followed 1,745 healthcare workers in 20232024 and looked at self-reported "influenza-like illness" (ILI) symptoms and sick leave. Recently boosted workers reported more ILI symptoms and more sick leave over the short term; by contrast, those who had seasonal flu vaccine reported fewer ILI symptoms and less sick leave. The paper's authors conclude that short-term benefits of COVID boosters in low-risk, working-age adults weren't clear in that post-pandemic window, and they explicitly call for more work to guide future booster policy. NaturePubMed
• Important limitations: outcomes were self-reported symptoms and work absence, not lab-confirmed infections or severe outcomes; COVID testing had been de-emphasized in that setting; and observational studies like this are prone to confounding (e.g., people who feel at higher risk may both choose boosters and be more likely to notice/report symptoms or stay home). The authors note these caveats. Nature
• The Cleveland Clinic research you referenced is often cited to claim "more doses more COVID." That early analysis (a 20222023 preprint) observed an association in employees during an Omicron wavebut it also emphasized potential confounding and did not show vaccines increase susceptibility. Fact-checkers flagged common over-interpretations of that work. A later Cleveland Clinic study (2024) in the same employee population estimated the 20232024 updated vaccine was ~42% effective against infection in working-age adults. MedRxivFactCheck.orgOxford Academic
• What public-health guidance says now: U.S. CDC guidance for 20242025 recommended an updated COVID-19 vaccine for most people 6 months, with extra doses prioritized for 65 or immunocompromised (shared decision-making for others). WHO/SAGE similarly prioritizes older and high-risk groups, with countries tailoring policies for lower-risk adults. That's broadly consistent with the Swiss paper's call for more targeted boosting in low-risk, working-age people. CDC+2CDC+2Pan American Health Organization

What this doesn't show

• It doesn't show that mRNA vaccines are net harmful overall, or that they "increase the risk of COVID." The Swiss study didn't measure COVID infections or severe disease; it measured short-term ILI symptoms and sick leave. Nature
• It doesn't overturn evidence that updated vaccines reduce severe outcomes, especially in older and high-risk peoplehence current prioritization for those groups. CDC

Bottom line

• The Swiss results are a useful, narrow signal: in a low-risk, working-age cohort, a recent booster wasn't linked to short-term symptom reduction and was associated with more self-reported ILI and sick leave during that period. That supports more targeted rather than universal, frequent boosting for healthy, younger adultsnot a blanket claim that "the risk-benefit no longer makes sense for most people." Risk-benefit still depends heavily on age, health status, timing since last infection/vaccine, and current circulation.

Assassin said:

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The stark reality is that the inflammation, myocarditis is a symptom of the damage done to the heart by the immune system in response to the cells in the heart producing a foreign protein.

Triggering the immune system to attack them.

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You really have no clue what you are talking about.

Tempus Edax Rerum said:

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Assassin said:

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The stark reality is that the inflammation, myocarditis is a symptom of the damage done to the heart by the immune system in response to the cells in the heart producing a foreign protein.

Triggering the immune system to attack them.

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You really have no clue what you are talking about.

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What are you gonna do for your birthday?

13 is a big step. You're on your way to being a he/him/his

Assassin said:

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Tempus Edax Rerum said:

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Assassin said:

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The stark reality is that the inflammation, myocarditis is a symptom of the damage done to the heart by the immune system in response to the cells in the heart producing a foreign protein.

Triggering the immune system to attack them.

---

You really have no clue what you are talking about.

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What are you gonna do for your birthday?

13 is a big step. You're on your way to being a he/him/his

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Yeah, we should all take advice as gospel from a guy who played gopher on a cruise ship.

Tempus Edax Rerum said:

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Assassin said:

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Tempus Edax Rerum said:

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Assassin said:

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The stark reality is that the inflammation, myocarditis is a symptom of the damage done to the heart by the immune system in response to the cells in the heart producing a foreign protein.

Triggering the immune system to attack them.

---

You really have no clue what you are talking about.

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What are you gonna do for your birthday?

13 is a big step. You're on your way to being a he/him/his

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Yeah, we should all take advice as gospel from a guy who played gopher on a cruise ship.

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And there were a total of 18 people in the world that did what I did when I was on them. That's 18 in the whole world.

Tell me about your birthday party

Assassin said:

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Tempus Edax Rerum said:

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Assassin said:

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Tempus Edax Rerum said:

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Assassin said:

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The stark reality is that the inflammation, myocarditis is a symptom of the damage done to the heart by the immune system in response to the cells in the heart producing a foreign protein.

Triggering the immune system to attack them.

---

You really have no clue what you are talking about.

---

What are you gonna do for your birthday?

13 is a big step. You're on your way to being a he/him/his

---

Yeah, we should all take advice as gospel from a guy who played gopher on a cruise ship.

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And there were a total of 18 people in the world that did what I did when I was on them. That's 18 in the whole world.

Tell me about your birthday party

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Ok, Gopher.

Tempus Edax Rerum said:

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Assassin said:

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Tempus Edax Rerum said:

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Assassin said:

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Tempus Edax Rerum said:

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Assassin said:

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The stark reality is that the inflammation, myocarditis is a symptom of the damage done to the heart by the immune system in response to the cells in the heart producing a foreign protein.

Triggering the immune system to attack them.

---

You really have no clue what you are talking about.

---

What are you gonna do for your birthday?

13 is a big step. You're on your way to being a he/him/his

---

Yeah, we should all take advice as gospel from a guy who played gopher on a cruise ship.

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And there were a total of 18 people in the world that did what I did when I was on them. That's 18 in the whole world.

Tell me about your birthday party

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Ok, Gopher.

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That's the extent of your diatribe? You wouldnt win a debate on the 3rd grade playground with that.

Assassin said:

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Tempus Edax Rerum said:

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Assassin said:

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Tempus Edax Rerum said:

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Assassin said:

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Tempus Edax Rerum said:

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Assassin said:

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The stark reality is that the inflammation, myocarditis is a symptom of the damage done to the heart by the immune system in response to the cells in the heart producing a foreign protein.

Triggering the immune system to attack them.

---

You really have no clue what you are talking about.

---

What are you gonna do for your birthday?

13 is a big step. You're on your way to being a he/him/his

---

Yeah, we should all take advice as gospel from a guy who played gopher on a cruise ship.

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And there were a total of 18 people in the world that did what I did when I was on them. That's 18 in the whole world.

Tell me about your birthday party

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Ok, Gopher.

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That's the extent of your diatribe? You wouldnt win a debate on the 3rd grade playground with that.

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Debating with Gopher isn't all it's cracked up to be.

Tempus Edax Rerum said:

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Assassin said:

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Tempus Edax Rerum said:

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Assassin said:

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Tempus Edax Rerum said:

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Assassin said:

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Tempus Edax Rerum said:

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Assassin said:

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The stark reality is that the inflammation, myocarditis is a symptom of the damage done to the heart by the immune system in response to the cells in the heart producing a foreign protein.

Triggering the immune system to attack them.

---

You really have no clue what you are talking about.

---

What are you gonna do for your birthday?

13 is a big step. You're on your way to being a he/him/his

---

Yeah, we should all take advice as gospel from a guy who played gopher on a cruise ship.

---

And there were a total of 18 people in the world that did what I did when I was on them. That's 18 in the whole world.

Tell me about your birthday party

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Ok, Gopher.

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dnt win a debate on the 3rd grade playground with that.That's the extent of your diatribe? You woul

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Debating with Gopher isn't all it's cracked up to be.

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Curious if you think calling me Gopher is some sort of slight. You seem to think so.

Assassin said:

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Tempus Edax Rerum said:

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Assassin said:

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Tempus Edax Rerum said:

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Assassin said:

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Tempus Edax Rerum said:

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Assassin said:

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Tempus Edax Rerum said:

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Assassin said:

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The stark reality is that the inflammation, myocarditis is a symptom of the damage done to the heart by the immune system in response to the cells in the heart producing a foreign protein.

Triggering the immune system to attack them.

---

You really have no clue what you are talking about.

---

What are you gonna do for your birthday?

13 is a big step. You're on your way to being a he/him/his

---

Yeah, we should all take advice as gospel from a guy who played gopher on a cruise ship.

---

And there were a total of 18 people in the world that did what I did when I was on them. That's 18 in the whole world.

Tell me about your birthday party

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Ok, Gopher.

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dnt win a debate on the 3rd grade playground with that.That's the extent of your diatribe? You woul

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Debating with Gopher isn't all it's cracked up to be.

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Curious if you think calling me Gopher is some sort of slight. You seem to think so.

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Curious if you have any scientific trainging other than playing gopher?

Assassin said:

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He actually went there.

RFK Jr. just dropped a bombshell on mRNA vaccine technology.

He says the COVID shots PROLONGED the pandemic and helped CAUSE the variants.

But that's not even the best part.

MAHA just leveled up. This might be Kennedy's biggest move yet.

🧵THREAD pic.twitter.com/tNKq1uJEt0

— The Vigilant Fox 🦊 (@VigilantFox) August 5, 2025

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Key Points:

• Kennedy's Claims: RFK Jr. stated that mRNA vaccines "fail to protect effectively" against respiratory infections and suggested they encourage viral mutations, prolonging pandemics. He cited these reasons for redirecting funding to "safer" vaccine platforms, such as whole-virus vaccines.
• Scientific Pushback: Experts, including Dr. Paul Offit, Dr. Peter Hotez, and Dr. Michael Osterholm, have strongly disputed Kennedy's claims, emphasizing that mRNA vaccines saved millions of lives during the COVID-19 pandemic. Studies, such as one from the World Health Organization (2024), estimate that mRNA vaccines prevented at least 1.4 million deaths in Europe alone, with global estimates reaching up to 19.8 million lives saved in their first year.
• Effectiveness of mRNA Vaccines: While mRNA vaccines may not fully prevent infection, they significantly reduce severe outcomes, hospitalizations, and deaths. A 2022 study in The Lancet Infectious Diseases found they prevented 14.419.8 million deaths globally. Their ability to be rapidly updated to target new variants is a key advantage over traditional vaccine platforms.
• Mutation Claims: Kennedy's assertion that mRNA vaccines caused variants lacks evidence. Variants like Delta and Omicron emerged due to natural viral evolution, particularly in unvaccinated populations where the virus could replicate unchecked. Vaccines reduce viral spread, which limits opportunities for mutations.
• MAHA and Anti-Vaccine Sentiment: The "MAHA" (Make America Healthy Again) movement, associated with Kennedy, has celebrated this move as a victory against "Big Pharma." Posts on X reflect this sentiment, with some claiming the decision exposes mRNA vaccines as harmful. However, these posts often amplify unverified claims, and the scientific consensus contradicts them.
• Implications: Experts warn that defunding mRNA research could weaken U.S. pandemic preparedness and innovation in treatments for diseases like cancer and HIV, where mRNA technology shows promise. Dr. Drew Weissman, a Nobel Prize winner for mRNA research, called the decision "crippling" for U.S. science.

Kennedy's claims appear to misalign with extensive peer-reviewed data on mRNA vaccine safety and efficacy. The suggestion that mRNA vaccines prolonged the pandemic or caused variants is not supported by credible studies and contradicts the understanding of viral evolution. His decision to halt funding may reflect a broader anti-vaccine stance, as evidenced by his history and actions like firing the CDC's vaccine advisory committee. This move risks undermining public health infrastructure and could have long-term consequences, especially if other nations advance mRNA technology while the U.S. falls behind.

RFK Jr. NEEDS your help!

The mRNA lobby is in full meltdown, pressuring Trump to overturn RFK’s decision to end funding for mRNA vaccines.

Now MAHA insiders are calling on you to speak up.

“The Secretary needs your support now, more than ever.”

Short thread🧵 pic.twitter.com/CNyCtrP450

— End Tribalism in Politics (@EndTribalism) August 7, 2025

NYT:

During the pandemic, mRNA vaccines went from the genetic sequence of the virus to human trials in under 70 days. They were evaluated in large, rigorous trials, meeting the same safety and effectiveness standards as other vaccines. By the end of 2021, they had saved an estimated 20 million lives globally, including more than one million in the United States. They reduced hospitalization and death rates, lowered the risk of long Covid and helped economies and communities reopen sooner.

Osodecentx said:

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NYT:

During the pandemic, mRNA vaccines went from the genetic sequence of the virus to human trials in under 70 days. They were evaluated in large, rigorous trials, meeting the same safety and effectiveness standards as other vaccines. By the end of 2021, they had saved an estimated 20 million lives globally, including more than one million in the United States. They reduced hospitalization and death rates, lowered the risk of long Covid and helped economies and communities reopen sooner.

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NY TImes, one of the biggest recipients of Big Pharma money.

Assassin said:

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Osodecentx said:

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NYT:

During the pandemic, mRNA vaccines went from the genetic sequence of the virus to human trials in under 70 days. They were evaluated in large, rigorous trials, meeting the same safety and effectiveness standards as other vaccines. By the end of 2021, they had saved an estimated 20 million lives globally, including more than one million in the United States. They reduced hospitalization and death rates, lowered the risk of long Covid and helped economies and communities reopen sooner.

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NY TImes, one of the biggest recipients of Big Pharma money.

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Take your tin foil hat off Gopher.

https://www.sciencedaily.com/releases/2025/08/250818102951.htm

https://www.nature.com/articles/s41598-025-16143-w

mRNA was key in the COVID-19 vaccine

Paul Offit vs. Vigilant Fox or Catturd? Yeah, I'll stick with Paul Offit, Gopher.

Tempus Edax Rerum said:

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Paul Offit vs. Vigilant Fox or Catturd? Yeah, I'll stick with Paul Offit, Gopher.

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Measles outbreak in Texas is over:

https://thefederalist.com/2025/08/19/west-texas-measles-outbreak-ends-foiling-medias-efforts-to-make-it-the-next-pandemic/

Side note: check out the education of this journalist

historian said:

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Measles outbreak in Texas is over:

https://thefederalist.com/2025/08/19/west-texas-measles-outbreak-ends-foiling-medias-efforts-to-make-it-the-next-pandemic/

Side note: check out the education of this journalist

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Due to RFK's promotion of the use of alternative treatments like high doses of Vitamin A, cod liver oil, and the steroid budesonide to treat measles. The Centers for Disease Control and Prevention (CDC) did update its guidance to include physician-administered outpatient Vitamin A.