“The more you open yourself up to the possibility that good things will happen the higher probability is that good things will in fact happen.”
— Jordan Peterson
— Jordan Peterson
Post here for exciting advancements in mRNA technology!
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706 Replies |
Last: 3 days ago by Tempus Edax Rerum
Any word about a meet up?LIB,MR BEARS said:I'm not a doctor but I stayed at a holiday inn express and have read your post. I dub the Methuselahron.reagan said:
There was an old lady that lived down the street from me growing up. She probably weighed 400lbs. She didn't believe in cholesterol or generally anything from the medical industry because her husband was also fat and lived into his late 80s. She also lived into her late 80s so I guess being ignorant her whole life actually paid off.
Waco1947
Here's an up-to-date summary of recent advances (2024-2025) in mRNA research:
Key Advances
[ol]
Improved mRNA sequence/design using AI and machine learning
New vaccine platforms and antigen design
Therapeutic applications beyond vaccines
Cancer vaccines and personalized mRNA immunotherapy
Delivery system and nanoparticle / LNP improvements
Regulatory / manufacturing improvements
New or expanded clinical trials / approvals
Emerging modalities
Structural prediction / folding / secondary structure advances
[/ol]
Key Advances
[ol]
- New models like RNop optimize mRNA for multiple objectives (fidelity of amino acid sequence, codon adaptation, tRNA availability, secondary structure) and do so with much greater computational efficiency. arXiv
- Helix-mRNA is a foundation model that handles full mRNA sequences (not just coding regions), including UTRs, with long sequences and fewer parameters. It improves predictive performance for translation, stability, etc. arXiv
- Equi-mRNA is a model that explicitly encodes synonymous codon symmetries (i.e. that different codons can encode same amino acid) to improve predictions of expression, stability, etc. arXiv
- Researchers at University of Pittsburgh / Penn State proposed a "trans-amplifying" mRNA vaccine format, where the antigen and replicase are on separate mRNAs. Because the replicase component can be produced/prepared in advance, this can reduce costs/dose and increase speed. In mice, this induced strong responses to many SARS-CoV-2 variants. University of Pittsburgh Health Sciences
- There is also work to identify "consensus" antigen sequences that cover many viral variants, to improve breadth of immunity. University of Pittsburgh Health Sciences
- Delivery of mRNA to make cells act like "long-lasting drug factories." For instance, engineering mRNAs with signal peptides so that the produced protein is secreted into the blood, extending the therapeutic effect vs. standard injections. Shown in mice for disease models such as psoriasis and cancer. NIBIB
- There are over 120 clinical trials underway for RNA-based cancer vaccines. MDPI
- One example: mRNA-4157 (Moderna) combined with pembrolizumab in melanoma showed a 44% reduction in recurrence risk vs. checkpoint inhibitor alone. MDPI
- Platforms are getting faster: manufacturing personalized vaccines is becoming more rapid. MDPI
- There is active work in improving lipid nanoparticle (LNP) carriers (better targeting, actives that reduce side effects, more efficient delivery) as well as exploring other delivery systems (such as polymer-based nanoparticles, exosomes, etc.) GlobeNewswire
- AI is being used to optimize both the mRNA components and the delivery vehicle design. For example, Everest Medicines has an AI + mRNA platform, with optimized third-generation sequence models and lipid libraries, applying them to both cancer and autoimmune disease vaccine/therapeutic programs. PR Newswire+1
- In vitro transcription (IVT) processes are being refined to improve yield and purity (especially reducing double-stranded RNA contaminants, which can trigger unwanted immune responses). GlobeNewswire
- Manufacturing time for personalized cancer vaccines is dropping (from ~9 weeks down to under ~4 weeks in some settings). MDPI
- Zapomeran (self-amplifying mRNA vaccine against SARS-CoV-2) has been approved in Japan and the EU. It's one of the first approved self-amplifying mRNA vaccines. Wikipedia
- Clinical trial progress in norovirus vaccines (Moderna's mRNA-1403 / Nova 301) is underway. The Guardian+1
- mRNA candidates for influenza, RSV, and other respiratory viruses are progressing. Moderna News+1
- Self-amplifying mRNA (saRNA) and trans-amplifying RNA (taRNA) are being pursued to allow use of lower doses, longer persistence, potentially lower cost. MDPI+2GlobeNewswire+2
- Circular RNAs (circRNA) are being explored in some settings because of potential for greater stability. MDPI
- Long-sequence folding of mRNA (secondary structure) remains challenging computationally. New methods combining quantum-centric optimization and classical post-processing are being tested. E.g. quantum sampling methods to handle folding for longer mRNA sequences. arXiv
Huge MAHA news coming from the White House tomorrow, you think it will be as exciting as a Tempus post?
“The more you open yourself up to the possibility that good things will happen the higher probability is that good things will in fact happen.”
— Jordan Peterson
— Jordan Peterson
Assassin said:
Huge MAHA news coming from the White House tomorrow, you think it will be as exciting as a Tempus post?
I like Tempus posts
Real huge Assassin. Already fell flat on its face and laughed at by serious Doctors.
Tempus Edax Rerum said:
Real huge Assassin. Already fell flat on its face and laughed at by serious Doctors.
Of which you are neither. Serious or a doctor
“The more you open yourself up to the possibility that good things will happen the higher probability is that good things will in fact happen.”
— Jordan Peterson
— Jordan Peterson
Assassin said:Tempus Edax Rerum said:
Real huge Assassin. Already fell flat on its face and laughed at by serious Doctors.
Of which you are neither. Serious or a doctor
Show me where I said I was a Doctor, gopher.
Tempus Edax Rerum said:Assassin said:Tempus Edax Rerum said:
fuReal huge Assassin. Already fell flat on its face and laughed at by serious Doctors.
Of which you are neither. Serious or a doctor
Show me where I said I was a Doctor, gopher.
I just think it's so cute that you think calling me Gopher is a dig. I could pinch your little punkin' cheeks!
“The more you open yourself up to the possibility that good things will happen the higher probability is that good things will in fact happen.”
— Jordan Peterson
— Jordan Peterson
Glad you think it's cute, gopher.
Tempus Edax Rerum said:
https://medicalxpress.com/news/2025-09-mrna-vaccine-age-macular-degeneration.html
Exciting. I have family members with Macular D
BREAKING: The #FDA #CDC #Pfizer & the rest misled the world. They claimed the COVID-19 vaccines were mRNA & that meant MESSENGER RNA (which occurs in life everywhere). It is NOT. The #mRNA is modRNA. #modRNA is a lab created hybrid designed to create changes in your genes. It… pic.twitter.com/ZfIYr5S0Wg
— Tom Renz (@RenzTom) August 19, 2023
“The more you open yourself up to the possibility that good things will happen the higher probability is that good things will in fact happen.”
— Jordan Peterson
— Jordan Peterson
Assassin said:BREAKING: The #FDA #CDC #Pfizer & the rest misled the world. They claimed the COVID-19 vaccines were mRNA & that meant MESSENGER RNA (which occurs in life everywhere). It is NOT. The #mRNA is modRNA. #modRNA is a lab created hybrid designed to create changes in your genes. It… pic.twitter.com/ZfIYr5S0Wg
— Tom Renz (@RenzTom) August 19, 2023
The brain worm is getting to you gopher.
The inventor of Mrna says its gene therapy not a vaccine. pic.twitter.com/cfMtxNQVSC
— Freyja™ (@FreyjaTarte) December 10, 2022
“The more you open yourself up to the possibility that good things will happen the higher probability is that good things will in fact happen.”
— Jordan Peterson
— Jordan Peterson
"Long mRNA"...
— Infectious Diseases Scandinavia (@ID_Denmark) August 13, 2025
Fake doctor @drseanmullen is trying to make money off his medical misinformation.
Please, Americans, do not give this grifter any money. pic.twitter.com/rNNp05SnTi
“The more you open yourself up to the possibility that good things will happen the higher probability is that good things will in fact happen.”
— Jordan Peterson
— Jordan Peterson
The Great mRNA Betrayal.
— Professor Ian Brighthope (@VirusFighterVi1) September 28, 2025
The Great mRNA Betrayal: A Reckoning for the Liars, Cheaters, and Con Artists Who Poisoned the World.
In the annals of human history, few crimes rival the sheer audacity and malevolence of the mRNA vaccine scam—a global con job orchestrated by a cabal… pic.twitter.com/ccxSAtO6Tu
“The more you open yourself up to the possibility that good things will happen the higher probability is that good things will in fact happen.”
— Jordan Peterson
— Jordan Peterson
“mRNA is not a vaccine, but an experimental genetic modification platform and the spike protein is a toxin which causes very serious health damage...which they've known this since 2015...”
— Died Suddenly (@DiedSuddenly_) September 25, 2025
🚨🚨🚨 pic.twitter.com/68myi5osZc
“The more you open yourself up to the possibility that good things will happen the higher probability is that good things will in fact happen.”
— Jordan Peterson
— Jordan Peterson
Bill Gates openly discussing self-assembling nanotechnology in mRNA.
— healthbot (@thehealthb0t) August 7, 2025
The COVID scam was always about transhumanism pic.twitter.com/3nD33XqLFE
“The more you open yourself up to the possibility that good things will happen the higher probability is that good things will in fact happen.”
— Jordan Peterson
— Jordan Peterson