Post here for exciting advancements in mRNA technology!

47,931 Views | 691 Replies | Last: 5 hrs ago by LIB,MR BEARS
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https://www.nature.com/articles/s41586-025-09655-y
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https://www.nbcnews.com/health/health-news/pfizers-mrna-flu-shot-outperforms-standard-flu-vaccine-late-stage-tria-rcna244814
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https://www.scientificamerican.com/article/scientists-explain-how-mrna-covid-vaccines-may-rarely-cause-myocarditis/
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https://www.cidrap.umn.edu/covid-19/mrna-covid-vaccines-tied-drop-death-rate-4-years
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https://phys.org/news/2025-12-scientists-smarter-mrna-therapy-cells.html
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https://www.dkfz.de/en/news/press-releases/detail/mrna-rejuvenates-aging-immune-system-the-liver-as-a-fountain-of-youth
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1. The "Fountain of Youth" for the Immune System
In December 2025, researchers at MIT and the Broad Institute published a landmark study showing that mRNA can rejuvenate the aging immune system.


  • The Breakthrough: They used mRNA to turn the liver into a "factory" that produces signaling proteins normally made by the thymus (which shrinks as we age).

  • The Result: In older subjects, this "immune reset" doubled the production of young T-cells, making their immune response to infections and vaccines as strong as that of a much younger individual. This could be a game-changer for protecting the elderly from future pandemics.
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2. "Smart" mRNA: Targeted Precision
One of the biggest hurdles in mRNA therapy has been "off-target effects"mRNA going where it isn't needed. In late 2025, Mount Sinai researchers developed cSMRTS (cell-selective modRNA translation system).


  • How it works: This mRNA has a built-in "on/off switch." It "senses" the environment inside a cell; if it detects it is inside a cancer cell, it turns on and produces a toxic protein to kill the cell. If it's in a healthy cell, it stays off.
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  • The Impact: This allows for much higher doses of treatment with nearly zero side effects in healthy tissue.
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3. Personalized Cancer Vaccines Entering Phase 3
The "holy grail" of oncologypersonalized vaccineshit a major milestone in 2025.
  • Moderna & BioNTech: Large-scale trials for melanoma and non-small cell lung cancer have shown that these vaccines (tailored to the specific mutations of a patient's own tumor) can reduce the risk of recurrence or death by up to 75% when combined with immunotherapy.

  • Pancreatic Cancer: Early 2025 data showed that these vaccines are proving effective even for "cold" tumors like pancreatic cancer, which were previously thought to be unreachable by the immune system.
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4. mRNA for Autoimmune Diseases
Instead of just suppressing the whole immune system (which leaves patients vulnerable to infection), researchers are now using mRNA to re-train it.

  • The "Inverse" Vaccine: New experimental therapies use mRNA to teach the immune system that certain "self" proteins (like those in the joints for arthritis or the brain for MS) are not enemies. This "resets" the immune system without shutting it down entirely.
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5. Next-Gen "1/100th Dose" Delivery
A major breakthrough in Lipid Nanoparticles (LNPs) was announced in November 2025.
  • New, highly efficient delivery particles can produce the same immune response as current vaccines using only 1% of the dose.
  • This not only makes the shots much cheaper to produce but significantly reduces common side effects like fever or arm soreness.
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The first H5 (Bird Flu) pandemic mRNA vaccine is moving into Phase 3 trials in early 2026, and the first regulatory approvals for mRNA cancer therapies are expected by late 2026.
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https://www.newscientist.com/article/2509211-benefits-of-mrna-cancer-vaccines-could-exceed-75-billion-in-us-alone/
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https://www.kxan.com/news/science/cedar-fever-cure-researchers-developing-vaccine-for-severe-allergies/
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https://www.cidrap.umn.edu/cholera/novel-cholera-vaccine-shows-promise-phase-1-trial
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https://www.scmp.com/presented/tech/topics/keep-tech-tuesday-hkstp/article/3340111/biotech-firm-poised-transform-mrna-medicine-game-defining-drug-delivery-technology
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https://www.foxbusiness.com/media/moderna-ceo-hails-breakthrough-mrna-cancer-vaccine-halves-melanoma-recurrence-risk-keytruda
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https://finance.yahoo.com/sectors/healthcare/articles/messenger-rna-mrna-market-projected-160100770.html
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https://phys.org/news/2026-04-sites-fungal-vesicle-hitchhiking-mrna.html
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https://www.the-scientist.com/chatgpt-and-alphafold-help-design-personalized-vaccine-for-dog-with-cancer-74227
LIB,MR BEARS
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LIB,MR BEARS said:



It's kind of embarassing how easily duped you are.


What the research actually shows

The work comes primarily from the Bandim Health Project, a Danish/African research group led by Dr. Peter Aaby and Dr. Christine Stabell Benn. It's not a "Danish government" discovery it's independent academic research conducted mainly in Guinea-Bissau and other low-income countries, not Denmark.
Their key findings:
  • In seven studies of BCG-vaccinated children, DTP vaccination was associated with a roughly 2.5-fold increase in mortality in girls, with no corresponding increase in boys.
  • Being DTP vaccinated versus not vaccinated was associated with approximately a 2.07-fold higher overall mortality.
  • After three doses of DTP, the female-to-male mortality rate ratio increased to about 1.66, meaning girls were dying at a higher relative rate than boys compared to unvaccinated children.
So the real numbers are roughly 2x overall and ~1.7x the female/male disparity not 10x. The 10x figure circulating online is a significant distortion.
Why this is complicated, not a simple lie
  • The researchers found that live attenuated vaccines (like measles, BCG, oral polio) appear to boost the immune system broadly, while non-live vaccines like DTP appear to increase overall mortality, especially among girls.
  • A separate Danish register-based study actually found the opposite that children with fewer DTP vaccinations experienced increased mortality raising the concern that the Bandim findings may be affected by residual confounding.
  • The WHO's SAGE review concluded there was not convincing evidence of a large sex-differential effect, though the majority of studies (7 of 10) did suggest DTP had some deleterious effect.
Bottom line
The "10x" claim is false and inflated. The real research is legitimate peer-reviewed science showing roughly a 2x increase in all-cause mortality associated with the whole-cell DTP vaccine in low-income country settings a genuine scientific controversy that WHO has been slow to act on according to the researchers. The effect is specific to the whole-cell DTP used in developing countries, not the acellular version used in the U.S. and Europe. There are also serious methodological debates about whether confounding explains the findings. It's a real unsettled question, but wildly different from the viral "10x" version.
LIB,MR BEARS
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LIB,MR BEARS said:




You really are ignorant.

This is a badly misleading claim, and there are multiple serious problems with it.
The study itself is deeply flawed:
The three physicians who reviewed all 325 autopsies and decided which (Science Feedback) deaths were caused by vaccination were McCullough, Hodkinson, and Makis all well-known for spreading COVID misinformation. This raises obvious objectivity concerns.
The "independence" of their review likely just meant these three biased individuals sat in separate rooms before sharing their largely pre-determined conclusions not independent in any meaningful scientific sense. (Tech ARP)
The study included no control group of unvaccinated autopsies for comparison a basic requirement for establishing causation. (Science Feedback)
They contradicted the original researchers:
105 of the 240 vaccine-attributed deaths came from a single Colombian study whose own authors found "no relation between cause of death and vaccination." The review authors also counted 24 of 28 autopsies from a Singapore study as vaccine-related, even though those original authors identified "no definite causative relationship" to mRNA vaccines. (FactCheck.org)
The sample is cherry-picked and tiny:
They selected 44 papers out of 678 studies, covering just 325 autopsies. By ignoring a representative sample, the authors manufactured a "74% death rate" that lacks scientific basis. (Tech ARP)
The mean age of death in the study was 70.4 years (ResearchGate) an age group with abundant pre-existing cardiovascular conditions that explain the very causes of death being attributed to vaccines.
Conflict of interest:
Several co-authors, including McCullough, are affiliated with The Wellness Company, which sells products claiming to "detoxify" the body from spike protein a direct financial interest in promoting vaccine fear. (Mythdetector)
The preprint was pulled:
The preprint was removed from The Lancet's preprint server because its methodology did not support its conclusions. (European Newsroom)
Bottom line: The 74% figure comes from a biased team reviewing a cherry-picked sample, overriding the conclusions of the original researchers, with no control group. It tells you how three vaccine skeptics classified a tiny selected set of autopsy reports not what actually caused those deaths. There is no evidence that COVID-19 vaccination increases overall mortality risk, and a wealth of data supports that COVID-19 vaccines protect against severe disease and death. (FactCheck.org)
LIB,MR BEARS
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LIB,MR BEARS
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